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Ketamine and esketamine are rapid acting antidepressants for Treatment for Depression . They have distinct differences in modern care, Ketamine is a racemic. They are similar rates of improvement, cost, and administration.Esketamine is a nasal spray administered in a clinic. Ketamine is usually given via intravenous infusion.Both can cause dizziness and high blood pressure, but side effects are generally short lived Ketamine preferred for rapid onset high effectiveness or when insurance coverage is not the primary factor, despite being off label.Esketamine preferred for regulatory approval, convenience , and safety monitoring.Primarily for patients with treatment-resistant depression those who have not responded to two or more traditional medications.Kitamines are typically administered 2 to 3 times per a week for a duration of 3 to 4 weeks. Many patients notice improvement after the first or second session, though full benefits usually emerge by the fourth to sixthTreatment.Esketamine treatment for typically involves an initial 4 week induction phase of twice weekly sessions .
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