DNA vaccine protection against SARS-CoV-2 has emerged as a promising strategy in the fight against COVID-19. DNA vaccines work by introducing a small, circular piece of DNA that encodes the spike protein of SARS-CoV-2 into the body. This DNA is taken up by cells, which then produce the spike protein, triggering an immune response. The immune system recognizes the spike protein as foreign and generates antibodies and T-cell responses to protect against future infection with the virus. DNA vaccines offer several advantages, including their stability at room temperature, ease of production, and ability to stimulate both humoral and cellular immunity. Research and clinical trials are ongoing to evaluate the safety, efficacy, and durability of DNA vaccines against SARS-CoV-2, with early results showing that they can provide strong protection against infection and reduce the severity of illness. As vaccine development continues, DNA vaccines may become an integral part of global efforts to control the COVID-19 pandemic.